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KMID : 1134820080370040452
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Journal of the Korean Society of Food Science and Nutrition
2008 Volume.37 No. 4 p.452 ~ p.458
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Hypoglycemic Effect of Fermented Soybean Culture Mixed with Mulberry Leaves on Neonatal Streptozotocin-Induced Diabetic Rats
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Hwang Kyo-Yeol
Kim Young-Hoon
Cho Yong-Seok
Park Young-Shik
Lee Jae-Yeon
Kang Kyung-Don
Kim Geun
Joo Dong-Kwan
Ahn Duk-Kyun
Seong Su-Il
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Abstract
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The effect of fermented soybean culture of Bacillus subtilis MORI mixed with mulberry leaves on the
lowering the levels of blood glucose and cholesterol was examined using neonatal streptozotocin-induced
diabetic (n-STZ) rats. B. subtilis MORI produces 1-deoxynojirimycin (DNJ), an α-glucosidase inhibitor. The
content of DNJ of soybean fermented culture mixed with mulberry was higher (4.1±0.0 mg/g dry base) than
that (1.5±0.0 mg/g) of mulberry. The concentration of 50% inhibition (IC50) against rat intestinal α-glucosidase
of soybean fermented culture mixed with mulberry was 5.6±0.1 μg/mL and that of mulberry was 17.0±0.5
μg/mL. Experimental groups of diabetic rats were randomly assigned to normal control group (NC group),
diabetic control group (DC group) and three diabetic groups fed with DNJ food product. One of the three diabetic
groups was M group (60 mg DNJ food product/kg) (DNJ food product containing 30% mulberry) and the other
two were MM-60 group (60 mg/kg) and MM-120 group (120 mg/kg) (DNJ-fortified food product containing
30% fermented soybean culture mixed with mulberry leaves). The glucose in serum was significantly decreased
in the MM-60 and MM-120 groups fed with DNJ-fortified food product for 4 weeks, compared with DC group.
Total cholesterol and triglyceride in serum were also lower in MM-60 and MM-120 groups than the DC group.
These results support that the fermented soybean culture of B. subtilis MORI mixed with mulberry leaves
improved the metabolism of blood glucose and lipid in the n-STZ rat model.
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KEYWORD
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Bacillus subtilis MORI, mulberry leaves, blood glucose, cholesterol, neonatal streptozotocin induced diabetic rat
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